There is nothing artificial about the effects of antidepressants. They alter abnormal levels of brain chemicals, and repair the damage to the brain that occurs due to mental illness. These chemical and structural problems have caused the changes in your mood, appetite, sleep, sexual drive, and interest that lead to the development of mental illness. When an antidepressant is working, you actually do feel less depressed and less anxious. And you should take the medication for an appropriate amount of time.