It takes time for your body to respond to a new antidepressant. It might take several weeks for the drug to be fully effective, but early on, within a few weeks, you should notice some changes. Some people find they are a little less irritable, or perhaps they have better energy or they are sleeping better. Reduced anxiety (or worry) often follows and then the depressed mood improves. The ultimate goal is to achieve remission or be symptom free, with normal functioning in all areas of your life. Your goal should be “to be well,” not just “better.” Don’t forget that there are many treatment choices now. If one doesn’t work, another likely will. It is not a good idea to jump from drug to drug, however. Each drug should be given a reasonable trial before it is changed.